Drug points: Purpuric rash associated with slow release morphine

Fulminant Purpuric Rash in a Toddler

Presentation of a patient with palpable purpuric rash.

Henoch Shonlein purpura (HSP) is a form of systemic vasculitis characterized by deposition of IgA dominant immune complexes in the small vessels. The triad of palpable purpuric rash on lower extremities, abdominal or renal involvement and arthritis is the typical presentation in this condition. The disease primarily affects children and is less common in adults. We report a case of a young fema...

Purpuric skin rash on extremities: Churg-Strauss syndrome

Yaumatei Dermatology Clinic, 12/F Yaumatei Specialist Clinic (New Extension), 143 Battery Street, Yaumatei, Kowloon, Hong Kong A 21-year-old lady presented with right foot pain and numbness and a subsequent asthmatic attack with multiple purpuric rashes over the extremities. Blood tests showed peripheral blood eosinophilia. The constellation of clinical features and skin biopsy result were cons...

Papular purpuric rash due to parvovirus B19 with distribution on the distal extremities and the face.

We describe 3 patients who presented with a distinctive clinical picture of the purpuric rash called "gloves-and-socks syndrome" which was characterized by an acral distribution of the rash that involved not only the distal part of the extremities but also the chin and perioral area. Serologic analysis for parvovirus B19 yielded positive results. Parvovirus B19 should be included in the evaluat...

Tumor associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their heterogeneous behavior. Model TNPs comprised of a fluorescent platinum(IV) pro-drug and a clinically-...